English: Relapse prevention

Depression is a commonly occuring condition in the general population. Depression often comes back when people are already recovered from the condition. That is why it is important that people who ever had a depression, pay attention to relapse prevention.

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Publications on PCT

Preventive Cognitive Therapy is an evidence-based form of therapy. There have been multiple publications, including randomised controlled trials, to investigate it’s efficacy:

2021

Breedvelt J. J. F., Warren F. C., Segal Z., Kuyken W., Bockting, C. L. H. (2021). Continuation of Antidepressants vs Sequential Psychological Interventions to Prevent Relapse in Depression: An Individual Patient Data Meta-Analysis. JAMA Psychiatry. Published online May 19, 2021. doi:10.1001/jamapsychiatry.2021.0823

2020

Brouwer, M. E., Molenaar, N. M., Burger, H., Williams, A. D., Albers, C., Lambregtse-van den Berg, M., & Bockting, C. L. H. (2020). Tapering antidepressants while receiving digital Preventive Cognitive Therapy during pregnancy: An experience sampling methodology trial. Frontiers in Psychiatry. doi.org/10.3389/fpsyt.2020.574357

Molenaar, N. M., Brouwer, M. E., Burger, H., Kamperman, A. M., Bergink, V., Hoogendijk, W. J. G., . . . Bockting, C. L. H., Lambregtse-van den Berg, M. P. (2020). Preventive cognitive therapy with antidepressant discontinuation during pregnancy: Results from a randomized controlled trial. Journal of Clinical Psychiatry, 81(4). doi:10.4088/JCP.19l13099

2019

de Jonge, M., Bockting, C. L. H., Kikkert, M. J., van Dijk, M. K., van Schaik, D. J. F., Peen, J., . . . Dekker, J. J. M. (2019). Preventive cognitive therapy versus care as usual in cognitive behavioral therapy responders: A randomized controlled trial. Journal of Consulting and Clinical Psychology, 87(6), 521-529. doi:10.1037/ccp0000395

Klein, N. S., Wijnen, B. F. M., Lokkerbol, J., Buskens, E., Elgersma, H. J., van Rijsbergen, G. D., . . . Bockting, C. L. H. (2019). Cost-effectiveness, cost-utility and the budget impact of antidepressants versus preventive cognitive therapy with or without tapering of antidepressants. BJPsych Open, 5(1), e12. doi:10.1192/bjo.2018.81

van Kleef, R. S., Bockting, C. L. H., van Valen, E., Aleman, A., Marsman, J. C., & van Tol, M. J. (2019). Neurocognitive working mechanisms of the prevention of relapse in remitted recurrent depression (NEWPRIDE): Protocol of a randomized controlled neuroimaging trial of preventive cognitive therapy. BMC Psychiatry, 19(1), 409. doi:10.1186/s12888-019-2384-0

2018

Bockting, C. L. H., Klein, N. S., Elgersma, H. J., van Rijsbergen, G. D., Slofstra, C., Ormel, J., . . . Burger, H. (2018). Effectiveness of preventive cognitive therapy while tapering antidepressants versus maintenance antidepressant treatment versus their combination in prevention of depressive relapse or recurrence (DRD study): A three-group, multicentre, randomised controlled trial. Lancet Psychiatry, 5(5), 401-410. doi:10.1016/s2215-0366(18)30100-7

Klein, N. S., Bockting, C. L.H., Wijnen, B., Kok, G. D., van Valen, E., Riper, H., . . . Smit, F. (2018). Economic evaluation of an internet-based preventive cognitive therapy with minimal therapist support for recurrent depression: Randomized controlled trial. Journal of Medical Internet Research, 20(11), e10437. doi:10.2196/10437

2016

Molenaar, N. M., Brouwer, M. E., Bockting, C. L. H., Bonsel, G. J., van der Veere, C. N., Torij, H. W., Hoogendijk, W. J., Duvekot, J. J., Burger, H. & Lambregtse-van den Berg, M. P. (2016). Stop or go? Preventive cognitive therapy with guided tapering of antidepressants during pregnancy: study protocol of a pragmatic multicentre non-inferiority randomized controlled trial. BMC Psychiatry, 16(1), 1. doi: 10.1186/s12888-016-0752-6.

2015

Bockting, C. L. H., Smid, N. H., Koeter, M. W., Spinhoven, P., Beck, A. T., & Schene, A. H. (2015). Enduring effects of Preventive Cognitive Therapy in adults remitted from recurrent depression: A 10 year follow-up of a randomized controlled trial. Journal of Affective Disorders, 185, 188–194. doi:10.1016/j.jad.2015.06.048

De Jonge, M., Bockting, C. L. H., Kikkert, M. J., Bosmans, J. E., & Dekker, J. J. (2015). Preventive Cognitive Therapy versus Treatment as Usual in preventing recurrence of depression: Protocol of a multi-centered randomized controlled trial. BMC Psychiatry, 15(1), 1. doi: 10.1186/s12888-015-0508-8

2009

Bockting, C. L. H., Spinhoven, Ph., Wouters, L. F., Koeter, M. W. J, Schene, A. H., & the DELTA study group (2009). Long term effects of preventive cognitive therapy in recurrent depression using: 5.5 years follow-up. Journal of Clinical Psychiatry, 70, 1621-1628. doi: 10.4088/JCP.08m04784

2006

Bockting, C. L. H., Spinhoven, P., Koeter, M. W. J., Wouters, L. F., Visser, I., Schene, A. H., & the DELTA study group (2006). Differential predictors of response to preventive cognitive therapy in recurrent depression: A 2-year prospective study. Psychotherapy and Psychosomatics, 75, 229-236. doi:10.1159/000092893