English: Relapse prevention

Depression is a commonly occuring condition in the general population. Depression often comes back when people are already recovered from the condition. That is why it is important that people who ever had a depression, pay attention to relapse prevention.

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Publications on PCT

Preventive Cognitive Therapy is an evidence-based form of therapy. There have been multiple publications, including randomised controlled trials, to investigate it’s efficacy:


Breedvelt J. J. F., Warren F. C., Segal Z., Kuyken W., Bockting, C. L. H. (2021). Continuation of Antidepressants vs Sequential Psychological Interventions to Prevent Relapse in Depression: An Individual Patient Data Meta-Analysis. JAMA Psychiatry. Published online May 19, 2021. doi:10.1001/jamapsychiatry.2021.0823


Brouwer, M. E., Molenaar, N. M., Burger, H., Williams, A. D., Albers, C., Lambregtse-van den Berg, M., & Bockting, C. L. H. (2020). Tapering antidepressants while receiving digital Preventive Cognitive Therapy during pregnancy: An experience sampling methodology trial. Frontiers in Psychiatry. doi.org/10.3389/fpsyt.2020.574357

Molenaar, N. M., Brouwer, M. E., Burger, H., Kamperman, A. M., Bergink, V., Hoogendijk, W. J. G., . . . Bockting, C. L. H., Lambregtse-van den Berg, M. P. (2020). Preventive cognitive therapy with antidepressant discontinuation during pregnancy: Results from a randomized controlled trial. Journal of Clinical Psychiatry, 81(4). doi:10.4088/JCP.19l13099


de Jonge, M., Bockting, C. L. H., Kikkert, M. J., van Dijk, M. K., van Schaik, D. J. F., Peen, J., . . . Dekker, J. J. M. (2019). Preventive cognitive therapy versus care as usual in cognitive behavioral therapy responders: A randomized controlled trial. Journal of Consulting and Clinical Psychology, 87(6), 521-529. doi:10.1037/ccp0000395

Klein, N. S., Wijnen, B. F. M., Lokkerbol, J., Buskens, E., Elgersma, H. J., van Rijsbergen, G. D., . . . Bockting, C. L. H. (2019). Cost-effectiveness, cost-utility and the budget impact of antidepressants versus preventive cognitive therapy with or without tapering of antidepressants. BJPsych Open, 5(1), e12. doi:10.1192/bjo.2018.81

van Kleef, R. S., Bockting, C. L. H., van Valen, E., Aleman, A., Marsman, J. C., & van Tol, M. J. (2019). Neurocognitive working mechanisms of the prevention of relapse in remitted recurrent depression (NEWPRIDE): Protocol of a randomized controlled neuroimaging trial of preventive cognitive therapy. BMC Psychiatry, 19(1), 409. doi:10.1186/s12888-019-2384-0


Bockting, C. L. H., Klein, N. S., Elgersma, H. J., van Rijsbergen, G. D., Slofstra, C., Ormel, J., . . . Burger, H. (2018). Effectiveness of preventive cognitive therapy while tapering antidepressants versus maintenance antidepressant treatment versus their combination in prevention of depressive relapse or recurrence (DRD study): A three-group, multicentre, randomised controlled trial. Lancet Psychiatry, 5(5), 401-410. doi:10.1016/s2215-0366(18)30100-7

Klein, N. S., Bockting, C. L.H., Wijnen, B., Kok, G. D., van Valen, E., Riper, H., . . . Smit, F. (2018). Economic evaluation of an internet-based preventive cognitive therapy with minimal therapist support for recurrent depression: Randomized controlled trial. Journal of Medical Internet Research, 20(11), e10437. doi:10.2196/10437


Molenaar, N. M., Brouwer, M. E., Bockting, C. L. H., Bonsel, G. J., van der Veere, C. N., Torij, H. W., Hoogendijk, W. J., Duvekot, J. J., Burger, H. & Lambregtse-van den Berg, M. P. (2016). Stop or go? Preventive cognitive therapy with guided tapering of antidepressants during pregnancy: study protocol of a pragmatic multicentre non-inferiority randomized controlled trial. BMC Psychiatry, 16(1), 1. doi: 10.1186/s12888-016-0752-6.


Bockting, C. L. H., Smid, N. H., Koeter, M. W., Spinhoven, P., Beck, A. T., & Schene, A. H. (2015). Enduring effects of Preventive Cognitive Therapy in adults remitted from recurrent depression: A 10 year follow-up of a randomized controlled trial. Journal of Affective Disorders, 185, 188–194. doi:10.1016/j.jad.2015.06.048

De Jonge, M., Bockting, C. L. H., Kikkert, M. J., Bosmans, J. E., & Dekker, J. J. (2015). Preventive Cognitive Therapy versus Treatment as Usual in preventing recurrence of depression: Protocol of a multi-centered randomized controlled trial. BMC Psychiatry, 15(1), 1. doi: 10.1186/s12888-015-0508-8


Bockting, C. L. H., Spinhoven, Ph., Wouters, L. F., Koeter, M. W. J, Schene, A. H., & the DELTA study group (2009). Long term effects of preventive cognitive therapy in recurrent depression using: 5.5 years follow-up. Journal of Clinical Psychiatry, 70, 1621-1628. doi: 10.4088/JCP.08m04784


Bockting, C. L. H., Spinhoven, P., Koeter, M. W. J., Wouters, L. F., Visser, I., Schene, A. H., & the DELTA study group (2006). Differential predictors of response to preventive cognitive therapy in recurrent depression: A 2-year prospective study. Psychotherapy and Psychosomatics, 75, 229-236. doi:10.1159/000092893